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What to Expect From Your B12 Injections The injection site determines how well your body absorbs the vitamin and how comfortable the experience is

2011 Aug;103(4):349-57

Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity

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It is possible that this relatively selective colonic mucosal involvement may reflect the qualitative or quantitative differences in colonic microbial flora (as opposed to the small intestine)