Changes in intestinal motility can result in either diarrhoea (if transit is accelerated in the intestines) or constipation (if colonic motility is reduced)
Direct effects of iodothyronines on excess fat storage in rat hepatocytes
[1]International Diabetes Federation, IDF Diabetes Atlas 10th Edition, diabetesatlas.org Middle Eastern ministries included GLP-1 agonists on essential medicines lists in 2025, signaling a policy-level acceleration of demand
Common side effects include nausea, vomiting, diarrhea, stomach pain, decreased appetite, and fatigue
Because the medication slows down your stomachs ability to empty, having a large volume of food in your system when the dose begins to take effect can lead to some temporary digestive discomfort
Preclinical research shows tirzepatide attenuates dopamine reward signaling and dose-dependently reduces voluntary alcohol consumption in rodent models