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Endocr Rev 27:736749 Doedens L, Opperer F, Cai M, Beck JG, Dedek M, Palmer E, Hruby VJ, Kessler H(2010) Multiple N -methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies J Am Chem Soc 132:81158128 Dorn LE, Petrosino JM, Wright P, Accornero F (2018) CTGF/CCN2 is an autocrine regulator of cardiac fibrosis