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Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory

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Se da un lato lincidenza di macroalbuminuria stata del 8,9% vs 11,3% nel gruppo placebo, le percentuali di declino del eGFR 30% e di necessit di dialisi hanno invece mostrato un andamento pressoch sovrapponibile nei due gruppi

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