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The review documented GLP-1s rapid inactivation by DPP-4 even before the hormone has left the gut raising the hypothesis that GLP-1s actions may be partially transmitted via sensory neurons in the intestine and liver expressing the GLP-1 receptor rather than solely through systemic endocrine circulation

We appreciate the support of Amanda Namchuk, Travis Hodges, Bonnie Lee, and Natascha Diekow, who contributed to the experiment endpoints and tissue collections

This possibility is reflected in its clinical plasma half-life, which in the first-in-human study was measured to 85104 hours when administered at a dosage of 250 mg/kg [224]

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2025;5:e73619

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