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4.3 Impaired glycolytic flux and TCA cycle disruption Extensive research has highlighted the association between AD and the dysregulation of key glycolytic enzymes, including hexokinase, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and pyruvate kinase (PK) (65, 66)

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JAMA (2010) 304:238996.10.1001/jama.2010.1706 45 NapoliEWongSHertz-PicciottoIGiuliviC

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Long-Term Concerns and the Need for Research While most reported side effects are mild and transient, its important to acknowledge the potential long-term concerns raised in research