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Notably, while initially demonstrated in patients with T2DM, recent landmark trials have shown that semaglutide also significantly reduces primary cardiovascular endpoint events (including cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) in obese patients without diabetes, substantially expanding their potential cardioprotective applications

Shan C, Liang Z

This effect is partially lost in GF mice, suggesting a microbiota-dependent mechanism

The GshF was successfully expressed in the mutant strains, however, the expression levels in the mutant strains were lower than those in the control strain ZJ000 (Fig

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