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It is also involved in muscle function, immune health, and cellular processes

Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects.

Available from: Accessed 31 Dec 2023 de Prada, P., Loveland-Curtze, J., & Brenchley, J

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Severe hypersensitivity reactions, including anaphylaxis, generalized urticaria, and hypotension, tachycardia, and bronchospasm, have been reported following local instillation or injection of methylene blue

In the last decade important reforms have occurred in spatial planning and disaster risk reduction, trying to bring a shift towards comprehensive and integrated planning and a shift focusing on risk rather than management of emergencies