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Additionally, there is mounting evidence of their favorable cardiovascular impact, making them potentially appealing pharmacologic agents of choice in the future

Safe alternatives include metformin, SGLT2 inhibitors (empagliflozin, dapagliflozin), DPP-4 inhibitors (sitagliptin, linagliptin), and exenatide immediate-release or lixisenatide, which do not carry thyroid cancer warnings

Importantly, these effects diminished over time, despite continued administration of GLP-1RA

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