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A shift from pink to clear in a B12-containing formulation suggests B12 degradation, most commonly caused by light exposure

Therapy with bovine pancreatic enzyme extracts is not sufficient to restore cobalamin absorption in dogs with EPI, as intrinsic factor appears to be species-specific

Many were forced to discontinue therapy or seek alternatives

Deficiency of folate with or without vitamin B12 deficiency impairs DNA synthesis, leading to cell death, ineffective red blood cell production, and anemia

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Regardless, the absence of reported side effects doesnt eliminate the need for caution