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A chronic low-grade inflammaging process is accompanied by immunosenescence, i.e., a gradual deterioration of the immune system with aging, especially the functions of adaptive immunity decline [7, 151]

Whole-cell recordings in brainstem slices have demonstrated that histamine depolarizes both MTNs and masseter motoneurons but suppresses MTNs via H1 receptors, thereby reducing synaptic efficiency of the jaw-closure reflex (Gemba et al., 2015)

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