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It should be noted that external environmental influences and cytosolic enzymes can also lead to ROS generation ( NNT Nicotinamide nucleotide transhydrogenase provides an important link between pyridine nucleotide generation by glucose and FFA, ROS and the thiol redox state (Figure 1)

GSSG is the cellular intermediate the cycle returns to GSH through the action of glutathione reductase

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This lack of homeostasis affects acidification of vesicles transported to the lysosomal compartment for degradation [114]