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Oxidative RNA damage can impair protein translation, and damaged RNA can degrade prematurely, further impairs the synthesis of essential proteins ( Regarding mitochondrial dysfunction involved in AD pathophysiology, it includes disturbances in oxidative phosphorylation (OXPHOS), and impaired energy metabolism as well as excess generation of ROS, altered mitochondrial biogenesis, transport and dynamics ( Autophagy Autophagy is an important pathway in removing abnormal protein aggregates in cells and plays an essential role in protein homeostasis ( Diagnostics and treatments of AD Due to severe cognitive impairment in patients with advanced AD, the cost of treatment and care seriously affects economic development ( Currently, there is only two classes of drugs approved for the treatment of AD: N-methyl D -aspartate (NMDA) antagonist (memantine), and cholinesterase inhibitors (tacrine, Donepezil, galantamine, rivastigmine)
Compliance with ethical guidelines Competing interests The authors declare that they have no competing interests
GLP-1 agonists, including liraglutide and semaglutide, promote weight loss by influencing several processes that are related to appetite and digestion
TL;DR: Both medications are effective for weight loss when used in recommended dosages and in combination with diet and exercise
For a 200-pound person, thats about 40 pounds
