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Dietary composition also likely plays a part in gut motility, as indicated by differential gut manometry responses to FODMAP infusions in IBS patients compared to healthy controls (38)

The critical detail: theres a 2-3 month delay between the triggering event (rapid weight loss) and when you actually notice increased shedding

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These effects are possibly mediated through mechanisms that include, but are not limited to, improved glycemic control, reduced hepatic lipid production, enhanced fatty acid oxidation, and upregulated LDL receptor activity [52], offering a multifaceted therapeutic strategy for both diabetes and its associated metabolic disturbances

IGF-DES has an incredibly short half-life of only 20 to 30 minutes

, Barlowe et al