Furthermore, enhanced treatment efficacy was confirmed for high-dose VitC in combination with several hormonal treatments such as oestrogen receptor ER and human epidermal growth factor receptor 2 (HER2) inhibitors in breast cancer cells [108], as well as for PARP inhibition in the treatment of AML-TET2 deficient cells [22] and JQ1 (thieno-triazolo-1,4-diazepine), a Bromodomain and extraterminal inhibitor, in the treatment of melanoma [36]
These bioactive compounds are associated with numerous health benefits, particularly in protecting neuronal function and reducing oxidative stress [57]
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Autophagy: the last defense against cellular nutritional stress
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Alternatively, neuronal cells are seemingly more susceptible to sulforaphanes activity
