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Nasal Spray Nasal bremelanotide has the longest history of any form of the drug

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Often, the reported mechanisms underlying proteolysis in cis, i.e., autoproteolysis, involve attack of a nucleophile, i.e., either Ser, Thr or Cys side chains, on the N-terminally preceding peptide bond through an N-O(S) acyl shift resulting in formation of an instable ester, which is hydrolyzed ultimately resulting in cleavage of the peptide chain 71,72,73,74,103,104,105

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