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In comparison of food intake during an ad libitum buffet meal, treatment with pramlintide resulted in an approximately 200 calorie decrease in food intake compared to placebo administration (430)

The FDA approval acknowledges that GLP-1 receptor agonists can play a vital role in reducing the risk of Major Adverse Cardiovascular Events (MACE), such as heart attack, stroke, and cardiovascular death, particularly in adults with established cardiovascular disease and obesity or overweight

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