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Together they established that the GLP-1 (7-37) synthesised by Mojsov encouraged the secretion of insulin in rat pancreatic islet cells

Semaglutide works on one receptor (GLP-1) while tirzepatide works on two receptors (GLP-1 and GIP)

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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

Its also prudent to coordinate care with mental health professionals when appropriate

In light of this information, NCL offers this advice to consumers when considering GLP-1 treatment options: Before seeking treatment with a GLP-1 drug, talk to your doctor or health provider to determine if you are a candidate for treatment based on your risk factors and degree of obesity