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Reactive astrocytes associated with prion disease impair the blood brain barrier

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However, whether it effects the vascular regulation of the optic nerve is unknown

[DOI] [PubMed] [Google Scholar] 31.Lenzen S., Drinkgern J., Tiedge M

Preclinical studies have shown that ferroptosis-preventing therapies, such as the GSH precursor N-acetylcysteine (NAC), iron-chelating agents like deferoxamine (DFO) and deferiprone (DFP), and specific ferroptosis inhibitors like ferrostatin-1 (Fer-1), can alleviate neurodegeneration and improve motor symptoms in PD animal models ( In this comprehensive review, we aim to summarize the multifaceted roles of ferroptosis in PD pathogenesis, elucidate the links between PD-associated pathogenic proteins and ferroptosis, and provide an overview of current clinical trials and the potential of ferroptosis in the early diagnosis and treatment of PD

No lethal dose has been identified across toxicology studies conducted to date