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PMID: 23460912

Kidney damage (rare, but possible if urine backs up into the kidneys)

Critical evaluation of pharmacokinetic and biodistribution data reveals that these issues remain major translational bottlenecks that must be addressed through rational design and precise redox profiling

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Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells

603 In an 18-month proof-of-concept open-label randomized study, no statistically significant treatment group differences in the prevalence of confirmed clinical neuropathy (CCN), IENFD, and nerve conductions were observed