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NO is a highly reactive free radical, enabling it to diffuse rapidly and easily through cell membranes

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Refaie MM, Amin EF, El-Tahawy NF, Abdelrahman AM (2016) Possible protective effect of Diacerein on Doxorubicin-induced nephrotoxicity in rats

Cell 185 , 6276 (2022)

The medication is clearly doing something, just not producing weight loss anymore