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Macrophage deletion led to increased tolerance to LPS challenge, but when rBDNF was administered after macrophage depletion, the therapeutic effects of rBDNF were lost, as indicated by no further reduction in histopathological injury, wet-to-dry ratio, BALF protein concentration, immune cell infiltration, and sepsis-induced mouse mortality (Fig

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mBio, 11(3): e0046520 Hatton A D, Malin G, Mcewan A G (1994)