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Retatrutide (Retara), a triple GIP/GLP-1/glucagon agonist, produced the highest mean weight loss in clinical trials (24.2% at 48 weeks)

Waiting for it

10.1016/j.freeradbiomed.2020.04.010 16 CaiY.HuangC.ZhouM.XuS.XieY.GaoS.et al (2022)

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Detecting atrophic gastritis upon gastroscopy strongly supports the diagnosis, as does a positive finding of autoantibodies against intrinsic factor in a blood sample

I think this is just another validation that its not their fault, that obesity has biological underpinnings.