In fact, because of the then-dominating lock-and-key model of protein action and the associated central paradigm of structural biology stating that a unique 3D structure of a protein determines its function, all techniques for protein analysis were specifically designed for the analysis of the structural properties, conformational behavior, and thermodynamic stability of ordered proteins
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Promoting fibroblast death has shown beneficial outcomes in models of fibrosis, for example with the administration of TNF-related apoptosis-inducing ligand (TRAIL) related compounds like TLY012, which reduced fibrosis in a model of scleroderma (117)
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