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For most people with adequate B12 levels, additional intake through energy drinks is unlikely to meaningfully affect energy or alertness

10.1111/scd.12685 [DOI] [PubMed] [Google Scholar] de Benoist B

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This duration of safety monitoring provides meaningful reassurance about sustained exposure effects that would not be apparent in brief trials

This timeframe balances practical portabilityallowing patients to travel or keep medications at their workplacewith safety margins that ensure the compound remains chemically stable