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In other words, TMAO may indirectly enhance NF-B signaling by inhibiting SIRT1

Updated 8/23/21.Accessed 10/3/23

Moreover, the analysis of lipid metabolism and inflammation regulators revealed higher gene expression of the fatty acid transporter cd36 , pparg , acc , hormone-sensitive lipase , tnfa and il6 in the peri-gonadal WAT of HFD-fed animals exposed to 3-BHA [210]

Keefe D, Kumar M, Kalmbach K

Denise C, Paoli P, Calvani M, Taddei ML, Giannoni E, Kopetz S , Kazmi SM, Pia MM, Pettazzoni P, Sacco E, Caselli A, Vanoni M, Landriscina M, Cirri P, Chiarugi P

Targeted intestinal delivery of incretin secretagoguestowards new diabetes and obesity therapies