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At the barrier level, aberrant intercellular junctional proteins (tight-junction, adherens-junction, and cytoskeleton-associated proteins) [9] and increased programmed cell death of intestinal epithelial cells [10] have been identified as key pathogenic mechanisms
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The planned efficacy outcomes were |||||||||| || |||||||| |||||| || ||||| ||| |||| ||| ||| || |||||||| ||||||| |||| ||||||| |||||| |||| |||||||| || ||||||| ||||||| |||||| |||| |||||||| || ||||||| |||||| |||| |||||||| || |||||||| ||||| ||||||||| ||||| ||||||||||| |||||||||||| ||| |||||| ||||||||| || |||||||| ||||||||| |||| ||||||||||| || |||||| ||||||| |||||||||| ||||||||| || |||||||| |||||||| |||||||||||||||| ||||||||| ||| ||||||| |||||||| |||||| ||| |||||| |||| |||||||| || ||||| |||||||||||||
Based on more accurate forecasting of trends and opportunities in their specific markets, firms will be in a strong position to communicate the true value of their product portfolios
No plan for dose titration, side-effect management, or urgent support means poor oversight
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