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A separate 2025 systematic review and meta-analysis published in the Journal of Thrombosis and Haemostasis analyzed 27 clinical trials involving more than 84,000 patients
"Semaglutide and muscle composition in adults with obesity." Diabetes, Obesity and Metabolism
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The next sections discuss what these trials reveal about mechanism: the time course of benefit, the imaging signature of plaque stabilization, and the limits of inference from each trial design
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