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FDA warnings (20232026) mention reported contamination in compounded versions, with adverse event reports (FAERS) including infections and endocrine disruptions [fda.gov]

Short-term studies frequently indicate minor side effects, including nausea and gastrointestinal distress (Cheng et al., 2001

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Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.

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The first tesamorelin human trials (Phase 1) began in the early 2000s, with Phase 3 trial dates spanning 2005-2008 (Study LIPO-010 Phase 3 completed 2008), leading to the November 2010 approval