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Wegovy, approved in 2021, has shown significant results in promoting weight loss, with clinical trial participants losing an average of 17-18% of their body weight over 68 weeks

doi: 10.1530/EJE-18-0175 66 ZelnikerTAWiviottSDRazIImKGoodrichELFurtadoRHM

Retatrutide has not yet received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)

A connected, reusable add-on provides advanced patient guidance and detailed injection logging, but adds user steps, which may be best suited to certain therapies where patient behavior is critical and closely monitored

The effect of INSL-5 on glucose homeostasis is less clear

Given its discovery just a few years earlier, GLP-1 was one of the sequences against which Raufman compared exendin-4