retatrutide trial Phase 2 of for Obesity VisualAbstract: Retatrutide reduces body weight

This is also where the choice between semaglutide and tirzepatide often shifts

The key distinction is the addition of glucagon receptor (GCGR) agonism

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At 48 weeks, 93% of participants on the 12 mg dose achieved normal liver fat levels (below 5%), with a mean relative reduction of 86% in hepatic fat content

As additional FDA submissions and real-world studies emerge, further clarification of optimal dosing strategies and sustained efficacy will shape its role in future metabolic treatment protocols