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An increased incidence of ataxia as a termination criterion could be observed with SHP099/trametinib/WA (Supplementary Fig

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The first study (ALA in Diabetic Neuropathy Study) enrolled 328 patients with symptomatic peripheral neuropathy and non-insulin-dependent diabetes mellitus who were randomized to receive an intravenous infusion of ALA at three different doses (1200 mg, 600 mg, or 100 mg/day) or a placebo for a period of 3 weeks

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