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Similar content being viewed by others Introduction Class B G protein-coupled receptors (GPCRs), whose endogenous ligands are peptide hormones, are key mediators of normal human physiology and serve as valuable drug targets for many diseases including diabetes, metabolic syndrome, osteoporosis, migraine, depression, and anxiety 1

Furthermore, circulating urate levels are intricately regulated by the balance between urate production and excretion, and the kidney plays a pivotal role in maintaining this homeostasis

10.3233/JAD-180959 29 ForsterR.SpziaF.PapineauD.SabadieC.ErdelmeierI.MoutetM.et al (2015)

Transcription factors such as NF- and AP-1 regulate cancer cell survival and proliferation and may be modulated in part by ROS

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