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To successfully employ an all-comers strategy moving forward, manufacturers need to ensure products have strong clinical and/or non-clinical differentiation, a robust data package that addresses a range of patient types and comorbidities, and well-funded physician and patient facing marketing campaigns

The upregulation of Nrf2 by Celastrol markedly enhances GPX4 expression, thereby preserving renal function and redox homeostasis

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The numerous small molecules that have been developed to either potentiate or inhibit NPY receptor offer promise for investigating NPY signaling in asthma [182]

(2013) 8:e63197