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Catalytic activity is prone to attenuation in the complex oral milieu owing to protein adsorption, pH fluctuations, and variable ionic strength, leading to suboptimal durability and limited functional persistence (Ming et al., 2020)

Galangin and naringin have also been shown to contribute to this tolerance-inducing process

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The compound requires specific environmental conditions to preserve its stability and prevent degradation

When Macugen was first approved, seventy percent of patients stabilized with no further severe visual loss (Gragoudas 2004)