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Sabry M, Halder SK, Allah AS, Roshdy E, Rajaratnam V, Al-Hendy A
Mutations found in the MRP6 gene are associated with genetic abnormalities of the autosomal inherited connective tissue disorder called pseudoxanthoma elasticum (PXE), which is characterized by the presence of dystrophic elastic fibers in the skin, retina, and large blood vessels, causing the appearance of bags in the skin, loss of vision and calcification of blood vessels [100]
Stoian et al
Thyroxine (T4) T4 consists of the amino acid tyrosine plus four iodine atoms
This energetic role is usually considered in the context of the specific vulnerability to TD of tissues with high energy demand, such as the heart and the brain
Even when the main compound patent expires, generic competitors must navigate a growing web of patents, making litigation and the delay of any market entry almost inevitable
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