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16.1%) Tirzepatide was superior on all five key secondary endpoints A post-hoc cardiovascular analysis published in European Heart Journal Open (September 2025) found tirzepatide was also associated with a greater predicted 10-year cardiovascular risk reduction an absolute reduction of 2.4% vs

2018 (tirzepatide discovery), and Coskun et al

We also thank Rui Yan and Wenjie Wang from Shanghai Applied Protein Technology for proteomic and bioinformatics analysis

doi: 10.1038/ncomms7118 145 YanaiharaNHirataYYamaguchiNNoguchiYSaitoMNagataCet al

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