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Exposed directly to the intestinal lumen, IECs express a wide array of pattern recognition receptors that enable microbial sensing

As such, the findings of this analysis may not be fully generalizable to the broader Japanese population with obesity disease, and interpretation should be limited to patient populations with clinical characteristics comparable to those represented in STEP and eligible under the Japanese treatment guidelines

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According to Sheetal Sapale, vice-president at research firm Pharmarack, major firms including Cipla, Sun Pharma, Dr Reddy's Laboratories, Biocon, Natco, Zydus and Mankind Pharma are readying branded generics, with many more likely to follow

For patients whose primary concern is heart protection, semaglutide's evidence base is unmatched

Wegovy will typically be administered at a low dosage and scaled up as the patient becomes used to the medication