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Potential benefits and harms must be balanced with any medical treatment, Bian said

PT-141's MC1R binding affinity is 50-fold lower than its MC4R affinity, meaning the dose required to produce melanogenesis would far exceed the dose that causes intolerable MC4R-mediated side effects like nausea and blood pressure elevation

doi:10.1080/17512433.2025.2450254

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Step 5: Slowly depress the plunger