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As a result, clinical development of new AOMs will become more expensive and operationally more challenging, e.g., exacerbating the already intense competition for obese patients during trial recruitment, while more onerous inclusion/exclusion criteria will make finding eligible patients even harder

10.1155/2013/657470 J

Post-Bariatric Surgery Dosing Requirements Those who have had bariatric surgery often need more B12 because their bodies dont absorb it well

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Also, gradual titration is commonly discussed in clinical guidance because delayed gastric emptying can cause nausea and vomiting, and dose escalation can help mitigate this

Postural orthostatic tachycardia syndrome (POTS) is a form of autonomic dysfunction characterised by an excessive increase in heart rate upon standing, without a significant drop in blood pressure