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Diarrhea affects 16-34% of retatrutide users depending on dose, making it the second most common GI side effect after nausea

What researchers are watching in the remaining trials With seven Phase 3 readouts expected this year, researchers have specific questions they want answered

Consequently, the 2024 American Gastroenterology Association (AGA) Rapid Clinical Practice Update recommends that management should depend on upper gastrointestinal symptoms

Short-acting GLP-1 receptor agonists such as exenatide immediate-release (Byetta) and lixisenatide (Adlyxin) must be administered within 60 minutes before meals

Any substantial weight loss (on a GLP-1 or not) sheds some lean mass alongside fat

Researchers are also exploring new compounds that could help preserve muscle mass during weight loss