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Next, -MSH binds to melanocortin-4 receptors (MC4R) found on second-order neurons in the hypothalamus, which relays signals to higher cortical centers that ultimately lead to early satiety

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Although functional heterogeneity within the GSH-low hES-MSC population remains unclear, it is more likely that GSH-low hES-MSCs are more heterogeneous and may consist of a mixture of cells in various states, including senescent and unhealthy states