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De Giorgi R, Ghenciulescu A, Yotter C et al (2025) Glucagon-like peptide-1 receptor agonists for major neurocognitive disorders

L.SilmanI.SussmanJ

Increased levels of ROS and lipid peroxidation products and/or decreased levels of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, and antioxidant compounds, such as glutathione, have been reported in both NAFLD/NASH patients as well as a variety of animal models of NAFLD 9,10,11,12,13,14

At the epigenetic level, decreasing NAD + /NADH ratio with age inhibits SIRT1/3 activity and impairs PGC-1-mediated mitochondrial biosynthesis and antioxidant gene expression [292, 293]

Selenium, sodium, and selenite increase the expression of antioxidant genes by acting on GPX4 and system Xc

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