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Dosing: Daily subcutaneous injection Maximum dose: 3.0 mg/day Average weight loss (SCALE trial): 8% over 56 weeks List price: ~$1,349/mo FDA-approved for: Adults and adolescents 12+ with BMI 30 (or 27 with comorbidities) Zepbound (Tirzepatide) The 2023 Newcomer Zepbound, FDA-approved in November 2023, contains tirzepatide a dual GIP/GLP-1 receptor agonist

Ideally the subjects would have come in for an EEG- or polysomnographic (PSG) monitored adaption night at the hospital ward the night before the study day

The reference lists of the full-text articles were additionally analyzed for further relevant studies

Retatrutide is a GLP-1/GIP/Glucagon triple agonist

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In addition, we specify the expected measurement noise assuming a log-normal distribution with constant standard deviation for each measured target