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Diacylglycerol and ceramide accumulation Consistent with the above studies, elevated plasma fatty acid concentrations can result in increased intracellular diacylglycerol (DAG) levels, leading to the activation of protein kinase C isoform (PKC-) and PKC- isoforms in skeletal muscles and liver respectively
Despite this important observation demonstrating histaminergic neurons are sensitive to key metabolic signals conveyed by the melanocortin system, the downstream mechanisms by which histaminergic neurons restrain the anorexigenic effects of melanocortin system activation remain to be identified
Treasure Island, FL, USA: 2025
doi: 10.1016/j.cej.2025.162678 119 PengP.FengT.YangX.DingR.WangJ.ChenP.et al
Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review
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