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5 Regulation of the pancreatic -cell by G protein-coupled receptor 40 (GPR40)

Long-term use has been shown to reduce the risk of major cardiovascular events by 14%, all-cause mortality by 12%, and hospitalizations for heart failure by 11%

A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs stop working for fat loss entirely

(1989) Dec;34(6):385-7