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Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression

However, problems begin to occur when the number of free radicals exceeds what our bodies can process naturally, resulting in an increased presence of free radicals that can damage cells and compromise bodily functions

This is a high response rate, especially considering these patients had already failed standard treatments

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Compared to classical ones, they have the advantage of being widely available, less expensive, more stable, and fewer side effects

Interest in the peptide comes primarily from animal research, gut-brain theories, and anecdotal reports