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Keywords : Semaglutide, Obesity, Pharmacotherapy, GLP-1 receptor agonist, Weight management, Metabolism Obesity is defined as an abnormal or excessive accumulation of body fat that impairs health, with a body mass index (BMI) 30 kg/m widely accepted as the diagnostic threshold[1]

These features are essential for oxygen transport, since RBCs have to undergo repeated shape changes without fragmentation, to assure their passage and oxygen perfusion through all vascular networks, namely, through capillary blood vessels with smaller lumen diameter than that of RBCs [6, 7]

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Whether GIP antagonism or agonism is the appropriate target for brain receptors is a subject to debate