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Additionally, RPD reduces IL-6, TNF- , IFN- , IL-10, IL-17A, IL-21, and IL-22 levels in the colon while increasing Treg-related cytokines, restoring intestinal immune Th17/Treg homeostasis (Luo et al., 2019)

Some people may experience mild side effects such as gastrointestinal discomfort, headache, or allergic reactions

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6 Challenges and future prospects 6.1 Molecular identification and clinical diagnosis challenges of PCH vs