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In a retrospective examination of data from 138 carcinogenicity studies in mice, increased liver weight at twelve months was typically associated with development of liver tumor by eighteen to twenty-four months (Carmichael et al

Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)